diff --git a/Include/internal/pycore_interp_structs.h b/Include/internal/pycore_interp_structs.h
index f11448b06696ad..723657e4cef10d 100644
--- a/Include/internal/pycore_interp_structs.h
+++ b/Include/internal/pycore_interp_structs.h
@@ -411,6 +411,7 @@ typedef struct _PyOptimizationConfig {
 
     // Optimization flags
     bool specialization_enabled;
+    bool uops_optimize_enabled;
 } _PyOptimizationConfig;
 
 struct
diff --git a/Python/optimizer.c b/Python/optimizer.c
index ab0ef3db4e4882..15a1eb5a17745b 100644
--- a/Python/optimizer.c
+++ b/Python/optimizer.c
@@ -1514,11 +1514,7 @@ uop_optimize(
     _PyBloomFilter *dependencies = &_tstate->jit_tracer_state->prev_state.dependencies;
     _PyUOpInstruction *buffer = _tstate->jit_tracer_state->code_buffer;
     OPT_STAT_INC(attempts);
-    char *env_var = Py_GETENV("PYTHON_UOPS_OPTIMIZE");
-    bool is_noopt = true;
-    if (env_var == NULL || *env_var == '\0' || *env_var > '0') {
-        is_noopt = false;
-    }
+    bool is_noopt = !tstate->interp->opt_config.uops_optimize_enabled;
     int curr_stackentries = _tstate->jit_tracer_state->initial_state.stack_depth;
     int length = _tstate->jit_tracer_state->prev_state.code_curr_size;
     if (length <= CODE_SIZE_NO_PROGRESS) {
diff --git a/Python/pystate.c b/Python/pystate.c
index 86dee70734a097..89374e16722494 100644
--- a/Python/pystate.c
+++ b/Python/pystate.c
@@ -522,6 +522,13 @@ is_env_enabled(const char *env_name)
     return env && *env != '\0' && *env != '0';
 }
 
+static inline bool
+is_env_disabled(const char *env_name)
+{
+    char *env = Py_GETENV(env_name);
+    return env != NULL && *env == '0';
+}
+
 static inline void
 init_policy(uint16_t *target, const char *env_name, uint16_t default_value,
             long min_value, long max_value)
@@ -619,6 +626,7 @@ init_interpreter(PyInterpreterState *interp,
                 SIDE_EXIT_INITIAL_BACKOFF, 0, MAX_BACKOFF);
 
     interp->opt_config.specialization_enabled = !is_env_enabled("PYTHON_SPECIALIZATION_OFF");
+    interp->opt_config.uops_optimize_enabled = !is_env_disabled("PYTHON_UOPS_OPTIMIZE");
     if (interp != &runtime->_main_interpreter) {
         /* Fix the self-referential, statically initialized fields. */
         interp->dtoa = (struct _dtoa_state)_dtoa_state_INIT(interp);